Therapeutic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 473/18 (2006.01) A61K 31/52 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 473/16 (2006.01)

Patent

CA 2654371

The invention relates to a method of improving oral drug absorption of adenosine analogues by the use of 2-methoxy adenosine pro-drugs and to the use of these pro-drugs as medicaments. The invention further relates to compounds that are pro-drugs of adenosine receptor agonists, and to their use as therapeutic compounds, in particular as analgesic or anti-inflammatory compounds, or as disease modifying antirheumatic drugs (DMARDs), and to methods of preventing, treating or ameliorating pain or inflammation using these compounds.

L'invention concerne un procédé permettant d'améliorer l'absorption de médicament par voie orale d'analogues d'adénosine par utilisation de promédicaments de 2-méthoxy adénosine, ainsi que l'utilisation de ces promédicaments comme médicaments. L'invention concerne également des composés qui sont des promédicaments des agonistes du récepteur de l'adénosine, ainsi que leur utilisation comme composés thérapeutiques, en particulier comme composés analgésiques ou anti-inflammatoires, ou comme médicaments contre les rhumatismes modifiant une maladie (DMARD), ainsi que des procédés de prévention, de traitement ou de soulagement de douleurs ou d'inflammations faisant appel à ces composés.

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