Therapeutic decapeptides

Details Therapeutic decapeptides Therapeutic decapeptides

C - Chemistry, Metallurgy

07

K

530/7.2, 167/103

C07K 7/06 (2006.01) C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1298683

60412-1558 ABSTRACT OF THE DISCLOSURE A decapeptide, and processes for its preparation, of the formula N-Ac-A1-A2-A3-Ser-Tyr-A4-A5-A6-A7-A8, wherein A is D-.beta.- Nal, D-p-X-Phe (where X is C1, F, Br, or CH3), D-Trp, or D-Phe; A2 is D-p-X Phe (where X is Cl, F, Br, or CH3), D-Phe, or D-Tyr; A3 is D-Phe, or D-Tyr; A4 is D-Arg, D-Lys, D-homo-Arg or D-diethyl- homo-Arg; A5 is Phe, Tyr, pentafluoro-Phe, .beta. -naphthyl-Ala, p-X- Phe (where X is C1, F, Br, or CH3), or Trp; A is Arg or Lys; A7 is Pro or OH-Pro; and A8 is D-Ala, D-Ala-NH2, Gly, or Gly-NH2; provided that at least one of A2 or A3 must be D-Phe; or a pharmaceutically acceptable salt thereof, are described. These decapeptides find use as an LH-RH analog.

506045

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