A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 31/711 (2006.01) A61K 38/50 (2006.01) A61K 39/245 (2006.01) A61K 47/10 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2174122
The present invention relates to compositions and methods for treating infectious diseases and genetic disorders through gene therapy and intracellular delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a therapeutic delivery composition effective for treating a disease state comprising an administerable admixture of an effective amount of a therapeutic compound capable of altering nucleic acid sequence function and an effective amount of a surface active nonionic block copolymer having the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 750 and approximately 15,000, preferably between approximately 2,250 and approximately 15,000, more preferably between approximately 3,250 and approximately 15,000, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 1 % to approximately 50 % by weight of the compound, preferably approximately 5 % to approximately 20 %.
L'invention porte sur des compositions et méthodes pour le traitement de maladies infectieuses et de troubles génétiques à l'aide d'une thérapie génique et d'un apport intracellulaire d'oligonucléotides antisens ou autres séquences d'acide nucléique, et notamment sur une composition efficace dans le traitements d'états pathologiques, faite d'un mélange administrable d'une dose efficace d'un composé capable de modifier la fonction de la séquence d'acide nucléique et d'une dose efficace d'un copolymère bloc non ionique de formule générale: HO(C¿2?H¿4?O)¿b?(C¿3?H¿6?O)¿a?(C¿2?H¿4?O)¿b?H où a représente un entier de sorte que l'hydrophobe représenté par (C¿3?H¿6?O) ait un poids moléculaire compris entre approximativement 750 et approximativement 15 000, de préférence entre approximativement 2 250 et approximativement 15 000 et encore mieux entre approximativement 3 250 et approximativement 15 000, et où b représente un entier de sorte que la portion hydrophile représentée par (C¿2?H¿4?O) constitue entre environ 1 % et environ 50 % en poids du composé ou mieux, entre environ 5 % et environ 20 %.
Allaudeen Hameedsulthan S.
Emanuele R. Martin
Kousoulas Konstantin G.
Cytrx Corporation
Finlayson & Singlehurst
LandOfFree
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