Therapeutic delivery of carbon monoxide

Details Therapeutic delivery of carbon monoxide Therapeutic delivery of carbon monoxide

A - Human Necessities

61

K

A61K 31/28 (2006.01) A61K 31/295 (2006.01) A61K 33/00 (2006.01) A61K 33/24 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 15/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 39/06 (2006.01) A61P 41/00 (2006.01) C07F 15/00 (2006.01) C07F 15/02 (2006.01) C07F 17/02 (2006.01)

Patent

CA 2447275

Metal carbonyls are used to deliver CO having biological activity, for example vasodilatation and inhibition of transplant rejection. The metal of the carbonyl is typically of groups 7 to 10, e.g. Fe and Ru. The carbonyl preferably has one or more ligands other than CO, such as amino acids, to modulate the CO release property and solubility.

Des carbonyles métalliques sont utilisés pour produire du CO ayant une activité biologique, par exemple la vasodilatation et l'inhibition des rejets de greffes. Le métal du carbonyle fait partie généralement des groupes 7 à 10, p.ex. Fe et Ru. Le carbonyle a de préférence un ou plusieurs ligands autres que du CO, tels que des acides aminés, permettant de moduler la libération et la solubilité d'émission du CO.

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