C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/755 (2006.01) A61K 38/17 (2006.01) A61K 38/37 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 16/36 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2130900
A polypeptide which is capable of inhibiting binding of von Willebrand factor (vWF) to platelets and consisting essentially of an amino acid sequence that corresponds to the amino acid sequence of that fragment of mature von Willebrand factor subunit having its amino terminus at about Cys5O9 and its carboxy terminus at about Cys695, said polypeptide comprising optionally a second and/or a third domain, the second domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Thr450 and its carboxy terminus at about Tyr508, or a subfragment or com-bination of subfragments thereof, and a third domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Asp696 and its carboxy terminus at about Gly727, or a subfragment or com-bination of subfragments thereof; and also a process for producing said polypeptides from encoding DNA sequences, and also a method of inhibiting or treating thrombosis in a patient which comprises administering to such patient an effective amount of a therapeutic composition comprising one or more polypeptides of the invention.
Ruggeri Zaverio M.
Ware Jerry L.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Scripps Research Institute
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