Therapeutic drug for suppressing functions of nkt cells...

Details Therapeutic drug for suppressing functions of nkt cells... Therapeutic drug for suppressing functions of nkt cells...

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 31/7032 (2006.01)

Patent

CA 2627640

Disclosed is a therapeutic agent for a disease in which an NKT cell or the stimulation of an NKT cell is involved in the aggravation of a morbid condition thereof. The therapeutic agent comprises a chemically synthesized glycolipid derivative represented by the formula (I) or a pharmacologically acceptable hydrate or solvate thereof as an active ingredient. (I) wherein R1 represents an aldopyranose residue; R2 represents a hydrogen atom or a hydroxyl group; A represents -CH2-, -CH(OH)-CH2- or -CH=CHCH2-; x represents an integer of 13-16; and y represents an integer of 0 to 25.

La présente invention concerne un agent thérapeutique visant une maladie dans laquelle des cellules NKT ou la stimulation de cellules NKT sont impliquées dans l'aggravation d'un état maladif. Ledit agent comprend, en tant qu'ingrédient actif, un dérivé de glycolipide de formule (I) obtenu par synthèse chimique, ou bien l'un de ses hydrates ou solvates acceptable sur le plan pharmacologique. Dans la formule (I), R<SUP>1</SUP> représente un résidu aldopyranose ; R<SUP>2</SUP> représente un atome d'hydrogène ou un groupe hydroxyle ; A représente -CH<SUB>2</SUB>-, -CH(OH)-CH<SUB>2</SUB>- ou -CH=CHCH<SUB>2</SUB>- ; x est un entier allant de 13 à 16 ; et y est un entier allant de 0 à 25.

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