A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) A61K 31/05 (2006.01) A61K 31/11 (2006.01) A61K 31/18 (2006.01) A61K 31/22 (2006.01) A61K 31/335 (2006.01) A61K 31/407 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2674773
The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat head trauma. Specifically, the present invention provides methods of treating head trauma comprising the steps of identifying a subject having suffered a head trauma and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of head trauma.
La présente invention concerne l'utilisation d'activateurs de protéine kinase ou des accélérateurs du facteur de croissance du nerf ou 'NGF' (Nerve Growth Factor), du facteur neurotrophique dérivé du cerveau ou 'BNDF' (Brain-Derived Neurotrophic Factor) ou d'autres facteurs neurotrophiques pour traiter le traumatisme crânien. L'invention concerne spécifiquement des procédés pour traiter le traumatisme crânien consistant à identifier un sujet ayant souffert d'un traumatisme crânien et à lui administrer une quantité suffisante d'une composition pharmaceutique comprenant un activateur de protéine kinase C (PKC) ou de l'acide 4-méthylcatéchol-acétique (MCBA) et un vecteur pharmaceutiquement admis pour traiter l'un au moins des symptômes du traumatisme crânien.
Alkon Daniel L.
Zohar Ofer
Blanchette Rockefeller Neurosciences Institute
Gowling Lafleur Henderson Llp
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