A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A61K 39/385 (2006.01) C07G 3/00 (2006.01) C07H 1/00 (2006.01) C07K 14/805 (2006.01) C08G 63/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2296700
Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may by synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as cross-linked hemoglobin, in the peripheral circulation.
Nouveaux composés polysaccharide destinés à décorer des surfaces biomoléculaires pour augmenter la taille isotrope et masquer l'antigénicité. Lesdits oligosaccharides peuvent être synthétisés en tant qu'unités disaccharide de répétition, ou peuvent être dérivés par hydrolyse acide de polysaccharides naturels. Ces sources naturelles comprennent les chrondroïtines obtenues à partir de cartilage de requin, ou l'acide hyaluronique. Les groupes sulfate polyanioniques contenus dans les fractions sucre confèrent des charges négatives qui repoussent les molécules de la paroi négativement chargée des capillaires, afin de prolonger la durée de rétention des molécules de médicament décorées, telles que de l'hémoglobine réticulée, dans la circulation périphérique.
Hai Ton That
Nelson Deanna J.
Pereira David E.
Baxter International Inc.
Sim & Mcburney
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