Therapeutic heterocyclic compounds

Details Therapeutic heterocyclic compounds Therapeutic heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2282890

(see formula I) The present invention is concerned with compounds of formula (I), wherein n is an integer of from 0 to 3; W is a group of formula (i), (ii) or (iii), wherein R is hydrogen or C1-4alkyl, X is -O-, -S-, -NH- or CH2, Y is oxygen or sulphur and the chiral centre (*) in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and Z is a group of formula (iv), (v) or (vi) wherein R1 and R2 are independently selected from hydrogen and C1-4 alkyl and R3 is hydrogen or C1-4 alkyl; and their salts, solvates and physiologically functional derivatives, with processes for their preparation, with medicaments containing them and with their use as therapeutic agents, particularly in the prophylaxis and treatment of migraine.

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