Therapeutic immune condition compositions and methods

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) C07K 16/30 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2383432

Disclosed are compositions for reducing an immune condition, such as inflammation or cancer, in an animal suffering from the immune condition or predisposed to suffer from the immune condition. The compositions comprise a binding agent that specifically binds to an adhesion molecules expressed on the surface of or released by a blood-borne cell or an endothelial cell lining a blood vessel, wherein the binding agent induces an immune response in the animal to the binding agent. Additional disclosed compositions comprise an agent that is capable of reducing inflammation and reducing cancer in an animal when administered to the animal in a therapeutically effective amount. Also disclosed are methods for administering such compositions to an animal suffering from or predisposed to suffer from the immune condition.

L'invention concerne des compositions permettant de réduire un état immunitaire, tel qu'une inflammation ou un cancer, chez un animal souffrant d'un état immunitaire ou étant prédisposé à souffrir d'un état immunitaire. Les compositions renferment un agent liant se liant de manière spécifique à une molécule d'adhésion exprimée sur la surface d'une cellule à diffusion hématogène ou d'une cellule endothéliale recouvrant un vaisseau sanguin ou libérée par celle-ci, l'agent liant induisant une réponse immunitaire chez l'animal au niveau de l'agent liant. L'invention concerne des compositions supplémentaires renfermant un agent qui est capable de réduire une inflammation et un cancer chez un animal lorsqu'elles sont administrées à l'animal dans une quantité efficace sur le plan thérapeutique. L'invention concerne également des méthodes d'administration de telles compositions à un animal souffrant de l'état immunitaire ou prédisposé à celui-ci.

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