Therapeutic immunization of hiv-infected individuals

Details Therapeutic immunization of hiv-infected individuals Therapeutic immunization of hiv-infected individuals

A - Human Necessities

61

K

A61K 39/21 (2006.01) A61K 31/7088 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2535645

The present invention provides an improved method for eliciting a therapeutic immune response in an individual infected with human immunodeficiency virus (~HIV~). The method comprises administering an adenoviral vaccine composition expressing an HIV antigen to an individual with controlled viremia. Immunization of infected individuals in this manner elicits a cellular- mediated immune response against the virus that is significant both in the level of the response and the breadth of the response. The therapeutic immune response that ensues is capable of effectively maintaining low titers of virus and, thus, offers the prospect of reducing individual dependency on antiviral therapy.

L'invention concerne une amélioration apportée à un procédé servant à provoquer une réponse immunitaire thérapeutique chez un individu infecté par le virus de l'immunodéficience humaine ("VIH"). Ce procédé consiste à administrer une composition de vaccin adénovirale exprimant un antigène VIH chez un individu présentant une virémie contrôlée. Une telle immunisation d'individus infectés provoque une réponse immunitaire à médiation cellulaire contre le virus dont le niveau et l'ampleur sont significatifs. La réponse immunitaire thérapeutique qui s'ensuit permet de maintenir efficacement de faibles titres viraux et laisse ainsi entrevoir une possibilité de réduire la dépendance d'individus vis-à-vis de la thérapie antivirale.

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