Therapeutic inhibitor of vascular smooth muscle cells

Details Therapeutic inhibitor of vascular smooth muscle cells Therapeutic inhibitor of vascular smooth muscle cells

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/04 (2006.01) A61K 31/131 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/337 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/519 (2006.01) A61K 31/551 (2006.01) A61K 31/704 (2006.01) A61K 35/44 (2006.01) A61K 47/48 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2212537

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilatation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.

L'invention concerne des méthodes d'inhibition de la sténose consécutive à un traumatisme vasculaire ou à une maladie chez un hôte mammalien, qui consistent à administrer à ce dernier une dose thérapeutiquement efficace d'un conjugué thérapeutique contenant une protéine se fixant aux muscles vasculaires lisses et qui s'associe de manière spécifique à la surface de la cellule du muscle vasculaire lisse, couplée à une forme galénique d'agent thérapeutique qui inhibe l'activité cellulaire de la cellule musculaire. L'invention porte également sur des méthodes de libération directe et/ou ciblée d'agents thérapeutiques dans les cellules de muscle vasculaire lisse qui induisent une dilatation et la fixation de la lumière vasculaire en inhibant la contraction de la cellule du muscle lisse, et en formant un extenseur biologique.

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