Therapeutic inhibitor of vascular smooth muscle cells

Details Therapeutic inhibitor of vascular smooth muscle cells Therapeutic inhibitor of vascular smooth muscle cells

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 31/4025 (2006.01) A61K 31/407 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2154698

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.

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