Therapeutic ion channel blocking agents and methods of use...

Details Therapeutic ion channel blocking agents and methods of use... Therapeutic ion channel blocking agents and methods of use...

C - Chemistry, Metallurgy

07

D

C07D 307/86 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/443 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/513 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2479481

Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis.

Cette invention porte sur divers ligands divalents qui se basent sur des dérivés khellinone. Ces dérivés peuvent être utilisés pour moduler l'activité du canal potassique dans des cellules, notamment l'activité des canaux Kv1.3 présents dans les lymphocytes T. Les composés peuvent également servir au traitement ou à la prévention de maladies auto-immunes et inflammatoires telles que la sclérose en plaques.

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