C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/454 (2006.01) A61P 25/28 (2006.01) C07D 261/08 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07D 491/044 (2006.01)
Patent
CA 2696609
The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B(MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
L'invention concerne un composé représenté par la formule I: dans cette formule A1, A2, A3, R1, X, Y et B ont n'importe laquelle des valeurs décrites dans la description. L'invention concerne aussi des sels de ces composés, des compositions comprenant ces composés et des procédés thérapeutiques qui comprennent l'administration de ces composés. Ces composés sont des inhibiteurs de la fonction de l'enzyme monoamine oxydase B (MAO-B) et conviennent pour améliorer la fonction cognitive et pour traiter des troubles psychiatriques chez des animaux.
Kaplan Alan P.
Keenan Terence P.
Mcriner Andrew J.
Helicon Therapeutics Inc.
Smart & Biggar
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