C - Chemistry – Metallurgy – 01 – B
Patent
C - Chemistry, Metallurgy
01
B
C01B 31/02 (2006.01) A61K 31/194 (2006.01) C07C 49/553 (2006.01) C07C 61/39 (2006.01) C07C 69/753 (2006.01)
Patent
CA 2517007
Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adduct of buckminsterfullerene of the general formula C60R3, wherein each R is independently selected from groups of the formula -CR1R2 wherein each R1 and R2 is independently selected from the group consisting of -H and -COOH, provided, however, that at least one of the R1,s and R2,s is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.
Tri-adduit de buckminsterfullerène à base d'acide malonique et d'acide acétique e,e,e répondant à la formule générale C¿60?R¿3?, dans laquelle chaque R est choisi indépendamment des autres parmi des groupes répondant à la formule CR?1¿R?2¿, où chaque R?1¿ et R?2¿ est choisi indépendamment de l'autre dans le groupe composé de H etCOOH, à condition que l'un au moins des R?1¿ et R?2¿ représente hydrogène. On décrit et on revendique également des procédés de préparation et des adduits précités leurs utilisations dans le traitement des lésions neuronales et dans le prolongement de la vie.
Dugan Laura L.
Hardt Joshua I.
Lovett Eva G.
Quick Kevin L.
Mcfadden Fincham
Washington University
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