Therapeutic method and composition utilizing...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2408547

Disclosed are methods and compositions for use in immunotherapy. These methods and compositions are particularly useful for exploiting dendritic cells to present an antigen to a patient, particularly where the patient has a disease associated with the antigen. The invention provides methods for treating a patient having a disease associated with an antigen. The methods according to the invention comprise combining ex vivo an antigen and an antigen-presenting cell binding agent specific for the antigen, and administering the composition to a patient suffering from a disease associated with the antigen, wherein the patient receives a therapeutic benefit.

L'invention concerne des méthodes et des compositions destinées à être utilisées en immunothérapie. Ces méthodes et ces compositions sont particulièrement utiles pour exploiter les cellules dendritiques afin qu'elles présentent un antigène à un patient, en particulier lorsque le patient présente une maladie associée à l'antigène. L'invention concerne des méthodes de traitement d'un patient présentant une maladie associée à un antigène. Les méthodes selon l'invention consistent à combiner ex vivo un antigène et un agent fixant des cellules de présentation d'antigène spécifiques à l'antigène, et à administrer la composition à un patient souffrant d'une maladie associée à l'antigène, le patient tirant un bénéfice thérapeutique.

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