A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/711 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) A61P 1/16 (2006.01) A61P 9/02 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2438590
Methods of preventing or treating diseases in association with a decrease in the expression of AOP-1 gene or AOP-1 which comprise: (1) transferring a nucleic acid encoding AOP-1 or a nucleic acid encoding a polypeptide having an amino acid sequence derived from the amino acid sequence of AOP-1 by addition, deletion or substitution of one or more amino acids and having the function of AOP-1, or (2) administering a substance enhancing the expression of AOP-1 gene, a substance enhancing the production of AOP-1 or a substance enhancing the function of AOP-1.
L'invention concerne des procédés de prévention ou de traitement de maladies en association avec une diminution de l'expression du gène AOP-1 ou de AOP-1, qui consistent (1) à transférer un acide nucléique codant AOP-1 ou un acide nucléique codant un polypeptide ayant une séquence d'acide aminé dérivée de la séquence d'acide aminé de AOP-1 par addition, suppression ou substitution d'au moins un acide aminé et ayant la fonction de AOP-1, ou (2) à administrer une substance renforçant l'expression du gène AOP-1, une substance renforçant la production de AOP-1 ou une substance renforçant la fonction de AOP-1.
Furuya Mayumi
Hattori Fumiyuki
Sugimura Keijiro
Asubio Pharma Co. Ltd.
Daiichi Suntory Biomedical Research Ltd.
Daiichi Suntory Pharma Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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