A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/07 (2006.01) A61K 9/127 (2006.01) A61K 31/20 (2006.01) A61K 31/203 (2006.01) A61K 31/50 (2006.01) A61K 31/525 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01)
Patent
CA 2503094
The invention provides a method for treating leukemia in a patient. The method comprises administering to the patient a substance that increases expression of folate receptor .beta. on leukemia cells in the patient, called a FR-.beta. inducer, and administering a folate-conjugated therapeutic that targets the leukemia cells in the patient. The invention also comprises pharmaceutical compositions containing one or both of a Fr-.beta. inducer and a folate- conjugated therapeutic. The invention also provides a kit for use in treating leukemia in a patient, the kit comprising an FR-.beta. inducer and a folate- conjugated therapeutic.
Cette invention concerne une méthode de traitement de la leucémie chez un patient. La méthode consiste à administrer audit patient une substance qui augmente dans les cellules leucémiques du patient l'expression du récepteur bêta du folate, appelé inducteur FR-<i>?</i>. La méthode consiste ensuite à administrer une conjugase du folate qui cible les cellules leucémiques du patient. L'invention concerne également des compositions pharmaceutiques contenant à la fois un inducteur FR-<i>?</i> et une conjugase du folate. Elle concerne en outre une trousse destinée au traitement de la leucémie chez un patient, qui contient un inducteur FR-<i>?</i> et une conjugase du folate.
Lee Robert J.
Ratnam Manohar
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Medical College Of Ohio
The Ohio State University Research Foundation
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