C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2556259
The present invention relates generally to therapeutic molecules useful for inducing apoptosis of particular cells such as, but not limited to, cancer cells and methods for generating and/or selecting same. The present invention further provides methods for inducing apoptosis of cells such as cancer cells and pharmaceutical compositions useful for same. The present invention further provides methods for generating or selecting therapeutic agents capable of inducing apoptosis of particular cells by the selective inhibition of pro- survival proteins. The present invention further provides a computational approach to therapeutic molecule design based on structure-binding characteristics.
L'invention concerne en général des molécules thérapeutiques utiles pour l'induction de l'apoptose de cellules particulières, telles que, entre autres, les cellules cancéreuses, et des méthodes de génération et/ou de sélection desdites molécules. L'invention porte également sur des méthodes d'induction de l'apoptose de cellules, telles que les cellules cancéreuses, et sur des compositions pharmaceutiques utiles pour ces méthodes. L'invention porte également sur des méthodes de génération ou de sélection d'agents thérapeutiques capables d'induire l'apoptose de cellules particulières par l'inhibition sélective de protéines du type pro-survie. L'invention porte sur une approche computationnelle de la conception de molécules thérapeutiques basée sur les caractéristiques de liaison de structure.
Adams Jerry M.
Chen Lin
Colman Peter M.
Day Catherine L.
Hinds Mark G.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Walter And Eliza Hall Institute Of Medical Research
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