C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C12N 15/13 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2680741
This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
La présente invention a trait à des anticorps qui se fixent spécifiquement à des neurotoxines botuliniques (par exemple, la BoNT/A, la BoNT/B, la BoNT/E, etc.) ainsi qu'aux épitopes fixés par ces anticorps et qui les neutralisent typiquement. Les anticorps et leurs dérivés et/ou autres anticorps qui se fixent spécifiquement aux épitopes de neutralisation fournis par la présente invention peuvent être utilisés de manière à neutraliser la neurotoxine botulinique et sont par conséquent également utiles dans le traitement du botulisme.
Garcia Maria Consuelo
Geren Isin N.
Lou Jianlong
Marks James D.
Razai Ali
Smart & Biggar
The Regents Of The University Of California
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