Therapeutic or prophylactic agent for leukemia

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/505 (2006.01) A61K 31/351 (2006.01) A61P 35/02 (2006.01) C07D 239/42 (2006.01) C07D 309/02 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2655801

Disclosed is a therapeutic or prophylactic agent for leukemia. The therapeutic or prophylactic agent comprises a glycine derivative having a specific structure such as a compound represented by the formula below [(E)-2-(2,6-dichlorobenzamide)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid] or a pharmacologically acceptable salt thereof as an active ingredient. The therapeutic or prophylactic agent shows excellent absorption properties and in vivo stability upon being orally administered and has a significant therapeutic or prophylactic effect.

L'invention concerne un agent thérapeutique ou prophylactique pour la leucémie. L'agent thérapeutique ou prophylactique comporte un dérivé de la glycine ayant une structure spécifique, tel qu'un composé représenté par la formule ci-après [acide (E)-2-(2,6-dichlorobenzamide)-5-[4-(isopropyl-pyrimidin-2-ylamino)phényl]pent - 4 - acide énoïque], ou un sel de celui-ci qui soit acceptable en pharmacologie en tant qu'ingrédient actif. L'agent thérapeutique ou prophylactique présente d'excellentes propriétés d'absorption et une stabilité in vivo lorsqu'il est administré par voie orale et possède un effet thérapeutique ou prophylactique significatif.

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