Therapeutic or prophylactic agent for multiple sclerosis

Details Therapeutic or prophylactic agent for multiple sclerosis Therapeutic or prophylactic agent for multiple sclerosis

C - Chemistry, Metallurgy

07

D

C07D 239/34 (2006.01) A61K 31/335 (2006.01) A61K 31/351 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 239/42 (2006.01) C07D 239/47 (2006.01) C07D 239/52 (2006.01) C07D 309/12 (2006.01) C07D 313/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2655573

Disclosed is a therapeutic or prophylactic agent for multiple sclerosis. The therapeutic or prophylactic agent comprises a glycine derivative having a specific structure (e.g., a compound [(E)-2-(2,6-dichlorobenzamide)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]) or a pharmacologically acceptable salt thereof as an active ingredient. The therapeutic or prophylactic agent shows excellent absorption properties and in vivo stability upon being orally administered and has a significant therapeutic or prophylactic effect.

L'invention concerne un agent thérapeutique ou prophylactique pour la sclérose en plaques. L'agent thérapeutique ou prophylactique comprend un dérivé de glycine ayant une structure spécifique (par exemple, un composé [acide (E)-2-(2,6-dichlorobenzamide)-5-[4-(isopropyl-pyrimidin-2-ylamino)phényl]pent-4-énoïque]) ou un sel pharmacologiquement acceptable de celui-ci comme ingrédient actif. L'agent thérapeutique ou prophylactique présente d'excellentes propriétés d'absorption et une stabilité in vivo lorsqu'il est administré par voie orale et a un effet thérapeutique ou prophylactique significatif.

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