Therapeutic polypeptides, nucleic acids encoding same, and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2451454

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

La présente invention concerne des séquences d'acides nucléiques qui codent des polypeptides de l'invention. L'invention concerne également les polypeptides codés par ces séquences d'acides nucléiques et des anticorps qui se lient de façon immunospécifique au polypeptide ainsi que des dérivés, des variantes, des mutants ou des fragments du polypeptide de l'invention, du polynucléotide ou du polypeptide spécifique de l'anticorps. L'invention concerne en outre des vecteurs, des cellules hôtes, des anticorps ainsi que des procédés à recombinaison permettant la production de ces polypeptides et nucléotides, mais aussi des modalités d'emploi correspondantes. L'invention concerne enfin des procédés thérapeutiques, de diagnostic et de recherche destinés au diagnostic, au traitement et à la prévention de troubles impliquant l'un des acides nucléiques humains et protéines de l'invention.

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