Therapeutic polypeptides, nucleic acids encoding same, and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 1/04 (2006.01) A61P 1/14 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 13/08 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006

Patent

CA 2440108

Diclosed herein are nucleic acid sequences that encode G-coupled protein- receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclodes therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

L'invention concerne des séquences d'acide nucléique codantes pour des polypeptides liées à une protéine G couplée au récepteur. L'invention concerne également des polypeptides codés par ces séquences d'acide nucléique, et des anticorps qui se lient de façon immunospécifique au polypeptide, ainsi que les dérivés, mutants variants ou fragments du polypeptide, polynucléotide ou anticorps susmentionné. L'invention concerne également des procédés thérapeutiques, de diagnostic et de recherche pour le diagnostic, le traitement et la prévention de troubles impliquant l'un quelconque de ces nouveaux acides nucléiques et protéines humains.

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