Therapeutic polypeptides, nucleic acids encoding same, and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2474649

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifcally bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

L'invention concerne des séquences d'acides nucléiques codant de nouveaux polypeptides. Elle concerne également des polypeptides codés par ces séquences d'acides nucléiques, et des anticorps qui se lient de manière immunospécifique au polypeptide, ainsi que des dérivés, des variants, des mutants ou des fragments du nouveau polypeptide, polynucléotide, ou anticorps spécifique du polypeptide. L'invention concerne en outre des vecteurs, des cellules hôtes, des anticorps et des méthodes de recombinaison permettant de produire les polypeptides et polynucléotides de l'invention, ainsi que des méthodes d'utilisation de ces derniers. L'invention concerne enfin des méthodes thérapeutiques, diagnostiques et de recherche utilisant l'un quelconque de ces nouveaux acides nucléiques et protéines humains pour diagnostiquer, traiter ou prévenir des troubles.

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