C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/01 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2613480
The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibit pro-survival molecules and which are capable of inducing or facilitates apoptosis of a target cell or cell population such as cancer cells. The present invention further provides methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules.
L~invention concerne de manière générale des molécules thérapeutiques utiles pour la modulation de l~apoptose dans une cellule cible ou dans une population de cellules. L~invention concerne plus particulièrement des agents thérapeutiques qui inhibent des molécules pro-survie et qui sont capables d~induire ou d~aider l~apoptose d~une cellule cible ou d~une population de cellules telles que des cellules cancéreuses. La présente invention décrit également des procédés de génération ou de sélection des molécules thérapeutiques et de compositions pharmaceutiques comprenant les molécules thérapeutiques.
Colman Peter Malcolm
Fairlie Walter Douglas
Huang David Ching Siang
Lee Erinna Faith
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Walter And Eliza Hall Institute Of Medical Research
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