Therapeutic, prophylactic and diagnostic agent for cancer,...

Details Therapeutic, prophylactic and diagnostic agent for cancer,... Therapeutic, prophylactic and diagnostic agent for cancer,...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/17 (2006.01) G01N 33/574 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2292757

A therapeutic or prophylactic agent for cancer is disclosed which damages the membrane and kills cancer cells, in particular of the blood-forming system, having membrane protein aggregates which contain several core histones or largely core-like histones and/or their parts. The therapeutic or prophylactic agent contains at least one pure histone or its active sequence section selected from the group composed of histone H1, H1 subtypes, H2A, H2B, H2A:H2B dimer, H3 and H4, covalent modified histones of the above-mentioned type and/or their active sections and functionally and structurally similar proteins (protamines, histone-like proteins of prokaryotic and archae bacteria).

L'invention concerne un agent thérapeutique ou prophylactique du cancer qui détruit la membrane de cellules cancéreuses et tue des cellules cancéreuses, notamment les cellules cancéreuses du système hématopoïétique qui contiennent des agrégats protéiniques membranaires avec plusieurs histones nucléaires ou des histonoïdes similaires dans une large mesure aux histones nucléaires et/ou leurs parties. L'agent thérapeutique ou prophylactique contient au moins une histone pure ou une section de sa séquence active sélectionnée dans le groupe constitué d'histone H1, des sous-types de l'histone H1, H2A, H2B, H2A:H2B dimère, H3 et H4, les histones modifiées covalentes du type susmentionné et/our leurs sections actives, et des protéines similaires du point de vue fonctionnel et structurel (protamines et protéines histonoïdes de bactéries procaryotes et d'archaeobactéries).

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