C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/08 (2006.01) A01N 43/16 (2006.01) A01N 43/90 (2006.01) A01N 65/00 (2006.01) A61K 31/365 (2006.01) A61K 31/366 (2006.01) C07D 493/10 (2006.01)
Patent
CA 2204361
The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
La présente invention concerne des quassinoïdes purifiés et isolés et analogues de quassimoïdes obtenus par synthèse à partir du squelette carboné du picrasane. Elle a trait à de nouvelles chaînes latérales en C-15 utilisant des agents hydrosolubles, tels que la glycine. Grâce à leurs propriétés anticancéreuses, antivirales et herbistatiques, ces quassinoïdes sont notamment indiqués dans des méthodes thérapeutiques, contre des tumeurs solides et des cellules infectées par le virus de l'immunodéficience humaine.
Corbett Thomas H.
Grieco Paul A.
Morre D. James
Valeriote Frederick A.
Indiana University Foundation
Indiana University Research And Technology Corporation
Purdue Research Foundation
Ridout & Maybee Llp
The Board Of Governors Of Wayne State University
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