Therapeutic ribozyme compositions and expression vectors

Details Therapeutic ribozyme compositions and expression vectors Therapeutic ribozyme compositions and expression vectors

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/08 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2066684

2066684 9104319 PCTABS00003 Hepatitis delta is used as a vector for inhibition of viral infection and to express proteins in vivo in a cell-specific manner. The scope of delta's use as a vector is broadened in the present invention in several important ways. For example, a delta RNA genome capable of self-replication is enlarged to carry additional information, either coding for messenger RNA for a protein, or for a targeted ribozyme, which can be delivered to liver cells using delta's normally infectious properties, or to other cell types using chimeric delta viral agents carrying altered surface proteins. In another embodiment, the delta vector is made self-limiting, so that its role in delivering targeted information is separated from its viral property of unlimited infectious replication. Targeting is achieved through the use of sequences flanking the delta sequences that have affinity for sites on RNA to be cleaved.

Affiliated with

Also associated with

Rating

Therapeutic ribozyme compositions and expression vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic ribozyme compositions and expression vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic ribozyme compositions and expression vectors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1829466