Therapeutic strategy for treating autoimmune and...

G - Physics – 01 – N

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G01N 33/48 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 31/437 (2006.01) A61K 31/4745 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) G01N 33/487 (2006.01) G01N 33/49 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2579353

Numerous diseases have been linked to the production of effector cells. The present invention relates to the realization that effector cells are cycling in these diseases. In addition, the present invention relates to the determination that regulator cells are cycling in degenerative diseases. Based on these realizations, the present invention provides methods for treating conditions such as autoimmune diseases, degenerative diseases, and graft- versus-host disease. The present invention also relates to methods of determining when therapy should be administered to a patient.

Il a été établi que de nombreuses maladies sont liées à la production de cellules effectrices. Cette invention concerne l'observation que ces cellules effectrices sont recyclées dans des maladies dégénératives. Sur la base de ces observations, l'invention fournit des procédés de traitement de troubles tels que les maladies auto-immunes, les maladies dégénératives et la réaction de greffe contre hôte. L'invention concerne également des procédés destinés à déterminer lorsqu'un traitement doit être administré à un patient.

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