Therapeutic system for administering clonidine transdermally...

Details Therapeutic system for administering clonidine transdermally... Therapeutic system for administering clonidine transdermally...

A - Human Necessities

61

K

167/156, 167/237

A61K 31/415 (2006.01) A61K 9/70 (2006.01)

Patent

CA 1089362

Abstract of the Disclosure Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a five-layer laminate of, from the top: a protective backing; a gelled, mineral oil- polyisobutene-clonidine reservoir lamina that contains the clonidine that is administered as a continuous constant dosage; a microporous membrane that controls the constant dosage rate; a gelled, mineral oil-polyisobutene- clonidine contact adhesive layer that contains the clonidine that is adminis- tered as a priming dose and the means by which the system is attached to the skin and a strippable coating laminar.

289824

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