Therapeutic system for administering scopolamine transdermally

Details Therapeutic system for administering scopolamine transdermally Therapeutic system for administering scopolamine transdermally

A - Human Necessities

61

F

167/156

A61F 7/02 (2006.01) A61K 9/70 (2006.01) A61K 31/46 (2006.01)

Patent

CA 1059909

Abstract of the Disclosure A therapeutic system in the form of a bandage that administers scopolamine base transdermally in an initial pulse of 10 to 200 mcg/cm2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 10 mcg/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene- scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.

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