Therapeutic system for the retarded and controlled...

A - Human Necessities – 61 – K

Patent

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167/159, 167/164

A61K 9/70 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2010225

The present invention relates to a therapeutic system for the retarded and controlled transdermal and transmucous administration of active substances via an impermeable backing layer, an active substance containing reservoir, a substantially drug-free but drug-permeable layer, and a removable protective layer, whereby the drug-free layer is brought into contact with the active substance reservoir only immediately prior or after application and then lies between reservoir and application surface, whereby at least a portion of the active substance diffusing from the reservoir is converted in the retardation layer into a non-bioavailable form. In this connection, the conversion into the non-bioavailable form may be carried out either by immobilization of the active substance, by chemical reactions, or by physical interactions.

Système thérapeutique pour l'administration retardée et contrôlée d'ingrédients actifs à travers la peau ou les muqueuses par l'entremise d'une couche d'appui imperméable, d'un réservoir d'ingrédient actif, d'une couche essentiellement exempte de médicament mais y étant perméable et d'une couche protectrice détachable. La couche exempte de médicament est mise en contact avec le réservoir d'ingrédient actif seulement immédiatement avant ou après l'application et repose entre le réservoir et la surface d'application. Au moins une portion de l'ingrédient actif diffusant du réservoir est convertie dans la couche ralentisseuse dans une forme non biodisponible. Dans cette connexion, la conversion dans la forme non biodisponible peut se faire soit par immobilisation de l'ingrédient actif ou réaction chimique ou interaction physique.

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