Therapeutic treatment for cardiovascular diseases

Details Therapeutic treatment for cardiovascular diseases Therapeutic treatment for cardiovascular diseases

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/395 (2006.01) A61K 31/407 (2006.01)

Patent

CA 2257693

A method for treating endothelial cell dysfunction, such as associated with cardiovascular disease are disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((27''-ethoxy)-3'''(O)-4'''-(N,N- dimethylamino)-butane)-bis-(3,3'indolyl)]-1(H)-pyrrole-2,5-dione hydrochloride salt.

Cette invention se rapporte à un procédé de traitement des dysfonctionnements des cellules endothéliales, tels que ceux associés aux maladies cardio-vasculaires, et notamment à l'utilisation de l'inhibiteur de protéine kinase C (PKC) sélectif vis-à-vis des iso-enzymes qu'est l'hydrochlorate de (S)-3,4-[N,N'-1,1'-((27''éthoxy)-3'''(O)-4'''-(N,N-diméthylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione.

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