A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/407 (2006.01)
Patent
CA 2311736
A method for treating neoplasms associated with an oncogenic form of ABL such as CML and ALL is disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N, N'-1,1'-((2'' -ethoxy)-3''' (O)-4'''-(N, N- dimethylamino) -butane)-bis-(3, 3'-indoly1)]-1 (H)-pyrrole-2, 5-dione and its pharmaceutically acceptable salts.
L'invention concerne un procédé de traitement de néoplasmes associés à une forme oncogène de leucémie d'Aberson telle que la leucémie myéloïde chronique et la leucémie myéloïde aiguë. Ce procédé fait en particulier intervenir l'inhibiteur de la protéine kinase C à sélectivité isoenzymatique, (S)-3,4-[N, N'-1,1'-((2'' -ethoxy)-3''' (O)-4'''-(N, N-dimethylamino) -butane)-bis-(3, 3'-indoly1)]-1 (H)-pyrrole-2, 5-dione, et ses sels pharmaceutiquement acceptables.
Ballas Lawrence M.
Jirousek Michael R.
Stramm Lawrence E.
Ways Douglas Kirk
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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