Therapeutic treatment for inhibiting vascular restenosis

Details Therapeutic treatment for inhibiting vascular restenosis Therapeutic treatment for inhibiting vascular restenosis

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 33/24 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61K 51/08 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C07K 14/52 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2181035

A composition suitable for administration to a warm-blooded animal comprising an antisense oligonucleotide to the C-C chemokine family typified by MCP-1 and MIP-1-Alpha which may or may not be labeled with a radionuclide by means of a chelate ligand capable of administration to an animal to produce reliable visual imaging of areas of potential restenosis or to produce therapeutic effects on areas of potential restenosis.

L'invention concerne une composition appropriée pour être administrée à un animal à sang chaud. Cette composition comprend un oligonucléotide antisens par rapport à la famille de C-C chémokine, typifiée par les protéines MCP-1 et MIP-1 alpha, qui peut ou non être marqué par un radionucléide au moyen d'un ligand chélateur. Cette composition peut être administrée à un animal pour produire des images visuelles fiables des zones de resténose potentielle ou pour produire des effets thérapeutiques sur ces dernières.

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