Therapeutic use of an agent that stimulates no or...

Details Therapeutic use of an agent that stimulates no or... Therapeutic use of an agent that stimulates no or...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61B 17/11 (2006.01) A61K 9/00 (2006.01) A61K 38/18 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61P 9/00 (2006.01) A61F 2/06 (2006.01)

Patent

CA 2270286

Vascular endothelial growth factor (VEGF) has utility in the treatment of intimal hyperplasia, hypertension and atherosclerosis, and of conditions susceptible to treatment with agents that produce nitric oxide or prostacyclin. Instead of VEGF, an equivalent agent such as an agonist of VEGF receptors may be given, as may nucleic acid encoding such an agonist. The agent may successfully be administered via the adventitial surface of a blood vessel, e.g. using a device which defines a reservoir between the body wall and the vessel's adventitial surface, the reservoir being at least part-filled by a pharmaceutical formulation containing the agent to be delivered.

Le facteur de croissance de l'endothélium vasculaire (VEGF) est utile dans le traitement de l'hyperplasie endoveineuse, de l'hypertension et de l'athérosclérose, et dans celui de pathologies pouvant être traitées avec des agents produisant du monoxyde d'azote ou de la prostacycline. On peut administrer, en lieu et place du VEGF, un agent équivalent, tel qu'un agoniste de récepteurs du VEGF, ou un acide nucléique codant ledit agoniste. Ledit agent peut être administré de manière satisfaisante par la surface adventitielle d'un vaisseau sanguin, par exemple au moyen d'un instrument délimitant un réservoir entre la paroi corporelle et la surface adventitielle du vaisseau, ledit réservoir étant au moins partiellement rempli d'une préparation pharmaceutique contenant l'agent à administrer.

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