C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2523001
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen- binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists.
La présente invention concerne des antagonistes de CS1 qui se lient à CS1 et qui neutralisent au moins une activité biologique de CS1. Cette invention se rapporte également à une composition pharmaceutique renfermant de tels anticorps ou des fragments à liaison antigénique de ces anticorps, et à une méthode de prévention ou de traitement des états pathologiques comprenant les maladies auto-immunes et le cancer, chez un sujet nécessitant un tel traitement ou une telle prévention, qui consiste à administrer audit sujet, une quantité efficace de tels antagonistes.
Landolfi Nicholas F.
Tso J. Yun
Williams Marna
Abbott Biotherapeutics Corp.
Protein Design Labs Inc.
Smart & Biggar
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