A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/10 (2006.01) A61K 31/198 (2006.01) A61K 31/28 (2006.01) A61K 33/24 (2006.01)
Patent
CA 2265983
Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum- containing chemotherapeutic agent. Combinations of these time periods can also be employed.
L'invention concerne une méthode de prévention ou de réduction de perte de l'ouïe ou de l'équilibre, de dommages causés aux cellules de l'oreille, de perte de poids, de toxicité gastro-intestinale, de neurotoxicité ou d'alopécie, et de prolongement de la durée de vie de patients soumis à un traitement comprenant des quantités thérapeutiquement efficaces d'agents chimiothérapeutiques contenant du platine, tels que la cisplatine. Ces méthodes consistent à administrer une quantité efficace d'un agent protecteur méthionine, tel que la méthionine D, avant l'administration de l'agent chimiothérapeutique contenant le platine, simultanément à cette opération ou après celle-ci. On peut également combiner ces périodes de temps.
Smart & Biggar
The Board Of Trustees Of Southern Illinois University
LandOfFree
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