Therapeutic use of methionine for the treatment or...

A - Human Necessities – 61 – K

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A61K 31/095 (2006.01) A61K 31/198 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2543870

Methods of preventing or reducing mucositis in patients who have been exposed to toxic levels of radiation or who are undergoing treatment with platinum- containing anti-tumor compounds are provided. The methods comprise administering an effective amount of a protective agent comprising methionine or a methionine-like moiety to said patient prior to, simultaneously with, or subsequently to exposure to radiation or administration of a platinum- containing anti-tumor compound. Combinations of these time periods can also be employed.

L'invention concerne des procédés de prévention ou de traitement de la mucosite en cas d'exposition à des niveaux toxiques de rayonnement ou de traitement déjà en cours à base de composés antitumoraux qui contiennent du platine. On administre une quantité efficace d'agent de protection qui comprend de la méthionine ou une fraction du type méthionine, avant ou après l'administration des composés antitumoraux, ou encore simultanément avec elle. On peut aussi utiliser des combinaisons de la synchronisation d'administration considérée.

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