Therapeutic use of selective pde10 inhibitors

Details Therapeutic use of selective pde10 inhibitors Therapeutic use of selective pde10 inhibitors

C - Chemistry, Metallurgy

12

Q

C12Q 1/44 (2006.01) A61K 31/00 (2006.01) A61K 31/472 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2484600

The invention provides a method for treating certain neurologic and psychiatric disorders in mammals, including humans, comprising administration of a selective PDE10 inhibitor. In particular, the invention relates to treatment of mood, movement, and anxiety disorders; psychosis; drug, for example alcohol, addiction; disorders having as a symptom deficient cognition; and neurodegenerative disorders and conditions. The invention furthermore provides the use of papaverine as a selective inhibitor of PDE10. The invention also provides assays for identifying chemical compounds that have activity as selective PDE10 inhibitors.

L'invention concerne un procédé de traitement de certains troubles neurologiques et psychiatriques chez des mammifères, y compris chez des humains, consistant à administrer un inhibiteur sélectif de PDE10. En particulier, l'invention concerne le traitement de troubles de l'humeur, du déplacement et de l'anxiété; de la psychose; des troubles liés aux drogues, par exemple l'alcool, l'accoutumance; des troubles comportant un symptôme de déficience cognitive; ainsi que des troubles et des états pathologiques neurodégénératifs. L'invention concerne également l'utilisation de papavérine en tant qu'inhibiteur sélectif de PDE10. L'invention concerne encore des essais permettant d'identifier des composés chimiques présentant une activité en tant qu'inhibiteurs sélectifs de PDE10.

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