Therapeutic use of specific ligand in msrv associated diseases

C - Chemistry – Metallurgy – 07 – K

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C07K 16/10 (2006.01) A61K 39/42 (2006.01)

Patent

CA 2729869

The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No 1, SEQ ID No 2, SEQ ID No 3 SEQ ID No 4, SEQ ID No 5 and SEQ ID No 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No 1), from 0 to 2 in CDR2(SEQ ID No 2), from 0 to 2 in CDR3(SEQ ID No 3), from 0 to 1 in CDR4(SEQ ID No 4), from 0 to 4 in CDR5(SEQ ID No 5), from 0 to 2 in CDR6 (SEQ ID No 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No 1 to SEQ ID No 6.

La présente invention concerne un ligand comprenant chacune des régions de détermination complémentaires (CDR) présentées dans SEQ ID N°1, SEQ ID N°2, SEQ ID N°3, SEQ ID N°4, SEQ ID N° 5 et SEQ ID N°6 ou une séquence comportant soit le nombre d'acides aminés substitués indiqué ci-dessous, de 0 à 3 dans CDR1 (SEQ ID N°1), de 0 à 2 dans CDR2 (SEQ ID N°2), de 0 à 2 dans CDR3 (SEQ ID N°3), de 0 à 1 dans CDR4 (SEQ ID N°4), de 0 à 4 dans CDR5 (SEQ ID N°5), de 0 à 2 dans CDR6 (SEQ ID N°6), soit des acides aminés substitués par d'autres acides aminés présentant des fonctionnalités et propriétés chimiques équivalentes au sein desdites séquences SEQ ID N°1 à SEQ ID N°6.

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