Therapeutic uses of bactericidal/permeability-increasing...

Details Therapeutic uses of bactericidal/permeability-increasing... Therapeutic uses of bactericidal/permeability-increasing...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185155

Improved therapeutic compositions, methods and uses of bactericidal/permeability-increasing protein (BPI) products involve use of dimeric forms of BPI protein product monomers characterized by enhanced in vivo biological activity. Preferred formulations include 50 pencent or more by weight dimeric product and preferred therapeutic uses include endotoxin neutralization and heparin neutralization.

L'invention se rapporte à des compositions, procédés et utilisations thérapeutiques améliorés de produits à base de protéines bactéricides/augmentant la perméabilité (BPI). Ces procédés impliquent l'utilisation, sous forme de dimères, de monomères du produit protéique BPI, caractérisés par une activité biologique in vivo accrue. Des formulations préférées comprennent au moins 50 % en poids du produit dimère, et les utilisations thérapeutiques préférées comprennent la neutralisation des endotoxines et de l'héparine.

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