Therapeutic uses of chemokine variants

Details Therapeutic uses of chemokine variants Therapeutic uses of chemokine variants

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/19 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2536082

Variants of homodimer-forming chemokines, such as human CCL2, having a single amino acid substitution in the dimerization interface that alters the pattern of hydrogen bonds and acting as an obligate monomer, can antagonize natural chemokines and have anti-inflammatory activity in vivo. These variants can be used as active ingredient in pharmaceutical compositions for the treatment of inflammatory, autoimmune, or infectious diseases.

L'invention concerne des variants de chemokines formant des homodimères, tels que CCL2 humain, qui comprennent une seule substitution acide aminé dans l'interface de dimérisation modifiant le motif de liaisons hydrogène et agissant comme un monomère obligatoire, peuvent avoir des chemokines naturelles pour antagonistes et une activité anti-inflammatoire in vivo. Ces variants peuvent être utilisés comme ingrédient actif dans des compositions pharmaceutiques pour traiter des maladies inflammatoires, auto-immunes ou infectieuses.

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