A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2237808
The invention provides methods of treatment using humanized immunoglobulins that specifically bind to alpha-4 integrin. The methods are useful for treatment of asthma, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, transplant rejection, graft versus host disease, tumor metastasis, nephritis, atopic dermatitis, psoriasis, myocardial ischemia, and acute leukocyte mediated lung injury.
Cette invention concerne des procédés de traitement dans lesquels on utilise des immunoglobulines qui se lient spécifiquement à l'alpha-4 intégrine. Ces procédés sont utiles pour traiter l'asthme, l'athérosclérose, la dégénérescence liée au SIDA, le diabète, la maladie intestinale inflammatoire, la polyarthrite rhumatoïde, le rejet de transplant, la maladie du greffon contre l'hôte, la métastase de tumeur, la néphrite, la dermatite atopique, le psoriasis, l'ischémie du myocarde et les lésions aiguës du poumon à médiation leucocytaire.
Bendig Mary M.
Jones S. Tarran
Leger Olivier J.
Saldanha Jose
Yednock Ted A.
Athena Neurosciences Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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