Therapeutic uses of melanin

Details Therapeutic uses of melanin Therapeutic uses of melanin

A - Human Necessities

61

K

A61K 31/785 (2006.01) A61K 31/40 (2006.01) A61K 33/22 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/43 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C12N 9/02 (2006.01) C12P 17/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2073180

The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.

Cette invention vise le traitement de maladies dégénératives des tissus qui ont perdu de la mélanine et qui ont une base embryologique commune, comme les tissus du système nerveux, par l'administration d'une substance active qui entraîne une augmentation de la concentration de la mélanine dans le tissu. Les substances actives en question comprennent la mélanine, des variants de la mélanine, des analogues de la mélanine, des dérivés de la mélanine, la tyrosinase, le gène de la tysosinase, l'hormone agissant sur la concentration de la mélanine et des combinaisons de ces substances. Parmi les maladies en question, on trouve la maladie de Parkinson, la maladie d'Alzheimer, la rétinite pigmentaire, la schizophrénie et la démence. Cette invention aide également à réparer les neurones chez un mammifère ayant subi des lésions aux neurones, par l'administration d'une dose efficace d'une substance active qui entraîne une augmentation de la concentration de la mélanine dans le neurone, de manière à favoriser la réparation du nerf. Cette invention sert de surcroît à protéger les mammifères contre les maladies causées par des toxines ou contre les effets néfastes d'une toxine, par l'administration d'une dose efficace de la substance active décrite ci-dessus.

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