Therapeutic uses of steroidal compounds

Details Therapeutic uses of steroidal compounds Therapeutic uses of steroidal compounds

A - Human Necessities

61

K

A61K 31/568 (2006.01) A61K 31/573 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2630441

A steroid derivative compound of formula (I) in which: one of R1 and R2 is hydroxy and the other is hydrogen; or R1 and R2 together represent oxo; R3 is hydrogen or hydroxy; and the dotted lines represent single or double carbon- carbon bonds; and pharmaceutically acceptable salts and esters thereof are useful for the prevention or treatment of pain, for improving nerve regeneration after nerve injury or damage or disease, for the prevention or treatment of brain injury, damage or disease and for neuroprotection. Particularly useful compounds are 11-hydroxy-.DELTA.4-androstene-3,17-dione and 11-oxo-.DELTA.4-androstene-3,17-dione or their derivatives.

L'invention concerne un composé dérivé stéroïde de formule (I) dans laquelle: un des restes R1 et R2 désigne hydroxy et l'autre, hydrogène; ou R1 et R2 représentent conjointement oxo; R3 désigne hydrogène ou hydroxy; et les pointillés représentent des liaisons carbone-carbone simples ou doubles. L'invention concerne également des sels pharmaceutiquement acceptables et des esters dudit composé, s'utilisant pour assurer la prévention ou le traitement de la douleur, pour améliorer la régénérescence nerveuse après blessure nerveuse, dommage nerveux ou maladie nerveuse, pour assurer la prévention ou le traitement de traumatismes crâniens, de lésions cérébrales ou de maladies cérébrales, ainsi que pour assurer la neuroprotection. La 11-hydroxy-.DELTA.4-androstène-3,17-dione et la 11-oxo-.DELTA.4-androstène-3,17-dione ou leurs dérivatifs constituent des composés particulièrement utiles dans ce contexte.

Affiliated with

Also associated with

Rating

Therapeutic uses of steroidal compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic uses of steroidal compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic uses of steroidal compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1718298