C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2628546
A method is disclosed for inducing an immune response against autologous high mobility group box 1 (HMGB1) in the autologous host. The method relies on specific active immunotherapy utilising variants of HMGB1 and targeting conditions such as cancer, Alzheimer's disease, atherosclerosis, and inflammatory disturbances. Typical modes of the invention utilises modified HMGB1 polypeptides that comprise a substantial fragment of at least one of the A and B boxes of HMGB1. Also provided are variant HMGB1 polypeptides and nucleic acid fragments encoding these as well as vectors and transformed host cells.
La présente invention concerne un procédé permettant d'induire une réponse immune contre la boîte HMGB1 (High Mobility Group Box 1) autologue chez l'hôte autologue. Le procédé repose sur une immunothérapie active spécifique utilisant des variants de HMGB1 et ciblant des états tels que le cancer, la maladie d'Alzheimer, l'athérosclérose et les troubles inflammatoires. Les modes de réalisation typiques de l'invention utilisent des polypeptides HMGB1 modifiés qui comprennent un fragment considérable d'au moins une des deux boîtes A et B de HMGB1. La présente invention concerne également des polypeptides HMGB1 de variants et les fragments d'acide nucléique les codant, ainsi que des vecteurs et des cellules hôtes transformées.
Bratt Tomas
Dal Degan Florence
Holmberg Jens
Nielsen Katja Bergholdt
Voldborg Bjoern
Pharmexa A/s
Sim & Mcburney
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