Therapeutical polyanhydride compounds for drug delivery

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/14 (2006.01) A61K 9/00 (2006.01) A61K 47/30 (2006.01) A61L 27/18 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/06 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/06 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2475253

Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol, or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drug to a host via the polymeric drug delivery systems. Medical implants based on the polymeric drug delivery system of the invention are also provided.

L'invention concerne des polyanhydrides qui permettent de fixer des médicaments à faible masse moléculaire contenant un groupe acide carboxylique et un groupe amine, thiol, alcool, ou phénol dans leur structure de manière à former des systèmes polymères d'administration de médicaments. L'invention concerne également des procédés permettant de produire des systèmes polymères d'administration de médicaments au moyen de ces bras de liaison polyanhydride, ainsi que des méthodes d'administration de médicaments à faible masse moléculaire à un hôte par l'intermédiaire de ces systèmes polymères d'administration de médicaments.

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